PDFAbstract: The principle of Biosensor based on total internal reflection of imaging ellipsometry, methodology, experimental setup and functions is reviewed, especially the settings of optimization condition, which has key importance for the biosensor sensitivity. The biosensor may be used for high throughput bio-interaction process detection between nucleic acid and protein, protein and protein, ligand and receptor, and even virus and ligand, etc. Some biomedical applications and an extension application of biological oxygen demand (BOD) detection are demonstrated.
Keywords: Biosensor, imaging ellipsometry, biomedical applications REFERENCES [1] Ligler F S, Taitt C R, Shriver-Lake L C, et al., ANAL BIOANAL CHEM 377, 2003, 469. [2] Engvall E, Perlmann P, IMMUNOCHEMISTRY 8, 1971, 871. [3] Aicher A, Brenner W, Zuhayra M, et al., CIRCULATION 107, 2003, 2134. [4] Chan W C, Nie S M, SCIENCE 281,1998, 2016. [5] Safsten P, Klakamp S L, Drake A W, et al., ANAL BIOCHEM 353, 2006, 181. [6] Huang H W, Chen Y, BIOSENS BIOELECTRON 22, 2006, 644. [7] Wang S F, Chiu M H, Lai C W, et al., APPL OPTICS 45, 2006, 6702. [8] Hutter E, Fendler J H, ADV MATER 16, 2004, 1685. [9] Jin G, Tengvall P, Lundstrom I, et al., ANAL BIOCHEM 232, 1995, 69. [10] Ladbury J E, Chowdhry B Z, CHEM BIOL 3, 1996, 791.
Cite this paper
Yu Niu, Gang Jin. (2018) Biosensor Based on Total Internal Reflection Imaging Ellipsometry. International Journal of Mechanical Engineering, 3 , 71-74
Copyright © 2018 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution License 4.0