Nigel Aylward



Relative Thermodynamic Stacking Constants of Deoxyribo Dinucleotides

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Thermodynamic data, base stacking, tRNAs, bacteriophage T4, anticodon, codon


Consistent relative stacking interaction energies have been calculated for the sixteen triply ionised deoxyribose dinucleotide structures in the g-g- conformation. These values are lower than for the corresponding ribose dinucleotides and allow the prediction of the composition and complete characterization of a poly deoxyribose nucleotide. When applied to the tRNAs of Bacteriophage T4 they show the anticodons to have the predicted composition and stacking energy. However, the codons have a higher stacking energy enabling them to be preferentially transcribed. The stacking energy for the corresponding ribose anticodon and codon are higher than for the deoxyribose anticodon and codon. The anticodon and codon may be silenced by the synthetic ribose codon and anticodon. The DNA of dinucleotides may be favourably transcribed with Watson-Crick base pairing with a possible 100% accuracy. The prebiotic codons could not be fully translated without a chance of error. The stability of the DNA anticodons has enhanced their preservation.

Cite this paper

Nigel Aylward. (2016) Relative Thermodynamic Stacking Constants of Deoxyribo Dinucleotides. International Journal of Biochemistry Research, 1, 7-16