Wei-Shen Su, Feng-Yi Yang
Ultrasound Attenuates Blood-Brain Barrier Disruption and Cerebral Edema after Traumatic Brain Injury in Mice
traumatic brain injury, ultrasound, blood-brain barrier, brain edema, BDNF
Traumatic brain injury (TBI) is often caused by accidents that disrupt the normal brain function. The blood-brain barrier disruption (BBBD) is considered to be the major cause of vasogenic brain edema and subsequent brain injury. Cerebral edema is a common life-threatening neurological complication after TBI. In this study, we explored whether ultrasound had a protective effect against BBBD and cerebral edema following TBI. A TBI animal model was established by controlled cortical impact (CCI) injury in mice. The degree of BBBD was assessed by the water content and Evans blue (EB) extravasation in the brain following ultrasound exposure. The results showed that low-intensity pulsed ultrasound (LIPUS) elevated the protein levels of BDNF and tight junction protein ZO-1 following TBI. Furthermore, ultrasound treatment attenuated brain edema and BBBD. Therefore, ultrasound may serve as a potential treatment modality for brain edema after TBI.
Cite this paper
Wei-Shen Su, Feng-Yi Yang. (2017) Ultrasound Attenuates Blood-Brain Barrier Disruption and Cerebral Edema after Traumatic Brain Injury in Mice. International Journal of Psychiatry and Psychotherapy, 2, 54-57